THE POTASSIUM UPTAKE AND RATE OF OXYGEN CONSUMPTION OF ISOLATED FROG SKELETAL MUSCLE IN THE PRESENCE OF INSULIN AND LACTATE
- 1 January 1956
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 34 (1) , 893-902
- https://doi.org/10.1139/y56-095
Abstract
Insulin (5.0 × 10−2 units per ml.) and lactate (5.0 × 10−3 M) caused an uptake of potassium by intact frog skeletal muscles in vitro, and a concomitant loss of potassium from the medium surrounding the muscles; this fluid was Ringer's solution containing 2.1 meq. of potassium per liter. Thus a movement of potassium against a high concentration gradient has been demonstrated. In general, the conditions under which potassium uptake occurred stimulated the oxygen consumption of the muscles. Monoiodoacetic acid (2.5 × 10−4 M) abolished the effect of insulin on the potassium uptake and greatly reduced its effect on the oxygen consumption.Keywords
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