Expression of different mitogen‐regulated protein/proliferin mRNAs in Ehrlich carcinoma cells
- 8 August 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 349 (3) , 343-348
- https://doi.org/10.1016/0014-5793(94)00698-9
Abstract
Results from in vivo and from serum‐free primary cultures of Ehrlich cells suggest that the expression of mitogen‐regulated protein/proliferin (MRP/PLF) mRNAs is not essential for proliferation of this murine tumor. Two sizes for MRP/PRL‐related open reading frames (ORFs) have been detected by reverse transcription/PCR amplification. They are almost identical to that reported for PLF‐1; but 20% of the amplified cDNA included a shorter ORF, which lacks the entire sequence corresponding to that of the exon 3 of the mrp/plf genes. Ehrlich carcinoma may represent a good model to study regulation of expression and physiological roles of MRP/PLFs in vivo.Keywords
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