Seizures induced by acute loxapine overdose

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Abstract
Records of 10 patients who had experienced acute loxapine overdose were reviewed. The most frequent medical complications were CNS depression, sinus tachycardia, hypertension and hypothermia; 6 patients had generalized major motor seizures, 1 had recurrent paroxysmal atrial tachycardia and 2 had transient renal insufficiency from rhabdomyolysis and myoglobinuria. Other clinical effects from loxapine overdose were predominantly anticholinergic. Loxapine-overdose patients should receive ECG monitoring and treatment of medical complications in an intensive care unit.

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