Cardiovascular Effects of Sustained Norepinephrine Infusions. III. Lactic Dehydrogenase Isoenzyme Release
- 1 May 1966
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 18 (5) , 616-619
- https://doi.org/10.1161/01.res.18.5.616
Abstract
Infusion of norepinephrine (NE) in dogs in doses of 1 to 4 µg/kg/min resulted in a rapid and dose related increase in serum lactic dehydrogenase (LDH) and those isoenzymes of LDH present in the heart. Histochemically definable lesions in the heart were correlated with the isoenzyme release produced by 2 and 4 µg/kg/min NE infusion. Evidence of LDH isoenzyme release from organs other than the heart was found only in dogs in the highest dose group that, in addition, had evidence of low cardiac output.Keywords
This publication has 9 references indexed in Scilit:
- EVOLUTION AND DIFFERENTIATION OF DEHYDROGENASES*Annals of the New York Academy of Sciences, 1961
- LACTIC DEHYDROGENASE ISOZYMES AND THEIR DISTRIBUTION IN NORMAL TISSUES AND PLASMA AND IN DISEASE STATES*Annals of the New York Academy of Sciences, 1961
- SIGNIFICANCE OF THE HETEROGENEITY OF LACTIC DEHYDROGENASE ACTIVITY IN HUMAN TISSUES*Annals of the New York Academy of Sciences, 1961
- Pathologic changes induced by 1-norepinephrineThe American Journal of Cardiology, 1960
- Intestinal Bleeding and Perforation Complicating Treatment with VasoconstrictorsAnnals of Surgery, 1959
- MULTIPLE FORMS OF ENZYMES: TISSUE, ONTOGENETIC, AND SPECIES SPECIFIC PATTERNSProceedings of the National Academy of Sciences, 1959
- Serum transaminase and alkaline phosphatase levels after large doses of norepinephrine and epinephrine in dogsAmerican Journal of Physiology-Legacy Content, 1959
- Increasing Prevalence of Unexplained Liver NecrosisNew England Journal of Medicine, 1957
- Renal Changes in Shock Treated with Levarterenol (Levophed)American Journal of Clinical Pathology, 1957