Early Retention of 237Pu + 239Pu in Mature Beagles

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Abstract
Five mature beagles, ranging in age from 57 to 84 months, were injected intravenously with about 0.05–0.1 μCi/kg of 239Pu(IV) citrate to which tracer amounts of the photon-emitter 237Pu had been added. Plutonium retention in liver and in non-liver tissue (mainly skeleton) was measured periodically in the living dogs for nearly 4 months after injection by a combination of total-body and partial-body counting. All excreta were collected during the first 21 days and analysed for their Pu content. One dog was sacrificed at 14 days and another at 118 days for distribution studies. About 17% (I4-20%) of the injected Pu was excreted in the urine and feces in the first 3 weeks, about the same as that excreted in a corresponding time period by beagles injected as young adults (14%), but substantially more than beagles injected as juveniles (11%). In contrast to juvenile beagles injected at 3 months of age, in which early retention was about 12% in liver and 68% in the skeleton, mature beagles retained about 30% in liver and 50% in the skeleton. Retention in young adult beagles injected at 17 months of age was similar to that of mature dogs. Relative distribution of skeletal plutonium among various bones was similar in the mature animals to that seen previously in young adults, but quite different from that of juveniles. A notable exception was the humerus for which there was no significant difference (P > 0.2) in the % of retained skeletal Pu represented by the humerus among the juvenile, young adult and mature dogs.

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