Effect of pyridoxal administration on the contents of pyridoxal phosphate and .GAMMA.-aminobutyric acid in mouse brain.
- 1 January 1978
- journal article
- research article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 24 (3) , 255-262
- https://doi.org/10.3177/jnsv.24.255
Abstract
Many mice treated with a high single dose of PL [pyridoxal] died in convulsions. The convulsions were very similar to those induced with some antivitamin B6 in several ways: a long latent period occurs before convulsions; PLP [pyridoxal phosphate] levels in brain decrease; and GABA levels in brain, especially in synaptosomal fraction, decrease. A deranged GABA metabolism in nerve ending may possibly be a major cause of the convulsions.This publication has 10 references indexed in Scilit:
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