Inhibitory effect of duramycin on partial reactions catalyzed by sodium-potassium adenosinetriphosphatase from dog kidney
- 1 January 1984
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 23 (2) , 385-389
- https://doi.org/10.1021/bi00297a031
Abstract
The polypeptide antibiotic duramycin inhibited the (Na+,K+) ATP purified from dog kidney. An analysis of its mode of action revealed that the formation of phosphoenzyme from Pi but not from ATP was inhibited. The rate of dephosphorylation of the phosphoenzyme formed from ATP was markedly reduced. In contrast to quercetin, duramycin did not inhibit K+-dependent p-nitrophenylphosphatase activity. The effect of duramycin was completely reversed by phospholipids.This publication has 9 references indexed in Scilit:
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