The complete amino acid sequence of oncomodulin — a parvalbumin‐like calcium‐binding protein from Morris hepatoma 5123tc
- 1 October 1983
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 136 (1) , 9-17
- https://doi.org/10.1111/j.1432-1033.1983.tb07698.x
Abstract
Oncomodulin is an acidic calcium-binding protein of 108 amino acids which has been detected only in tumors. The complete amino acid sequence of rat oncomodulin has been established, and the N-terminus shown to be N-acetylserine. Homology of the oncomodulin sequence with members of the troponin C superfamily of calcium-binding proteins was demonstrated, and putative calcium-binding domains were located. A further degree of homology was established between oncomodulin and the parvalbumins, including rat parvalbumin. Oncomodulin was therefore considered to be a parvalbumin-like calcium-binding protein.Keywords
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