Aminothiazolylglycyl derivatives of carbacephem antibiotics. II Synthesis and antibacterial activity of novel aminothiazolyl cephem compounds with hydroxypyridone moiety.
Open Access
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (2) , 182-189
- https://doi.org/10.7164/antibiotics.40.182
Abstract
The synthesis and antimicrobial activity of novel carbacephem antibiotics which have amido moiety of (S)-aminothiazolylglycyl side chain are described. Among them, the compound having 5-hydroxy-4-pyridon-2-carboxyl group (KT-4697) showed exceptionally strong activity against Pseudomonas aeruginosa as well as Gram-negative bacteria. A cephalosporin with this acyl group namely KT-4788 with methylpyridiniumthiomethyl group at C-3 was found to be the most active against Gram-positive and Gram-negative strains including P. aeruginosa.This publication has 0 references indexed in Scilit: