Lateral Hypothalamic Control of Killing: Evidence for a Cholinoceptive Mechanism
- 6 February 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3919) , 900-901
- https://doi.org/10.1126/science.167.3919.900
Abstract
In rats that would not ordinarily kill mice, lateral hypothalamic injection of crystalline carbachol, a cholinomimetic, elicited killing. Norepinephrine, amphetamine, serotonin, and sodium salts were ineffective at the same site. Carbachol was ineffective when injected into the medial, dorsal, or ventral hypothalamus. As additional evidence for a cholinoceptive mechanism, neostigmine elicited killing, and, in spontaneous killers, methyl atropine blocked it. The results indicate that the lateral hypothalamus contains a cholinoceptive component of an innate system that activates killing, and anticholinergic treatment can be used as a means of suppressing killing.Keywords
This publication has 6 references indexed in Scilit:
- Hypothalamic mechanisms for sexual, aggressive, and other motivational behaviors in the opossum, Didelphis virginiana.Journal of Comparative and Physiological Psychology, 1967
- Aggressive motivation in the ratAnimal Behaviour, 1965
- Electrode-cannulas for electrical or chemical treatment of multiple brain sitesElectroencephalography and Clinical Neurophysiology, 1964
- Emotional and autonomic responses following hypothalamic chemical stimulation.Canadian Journal of Psychology / Revue canadienne de psychologie, 1964
- Direct adrenergic and cholinergic stimulation of hypothalamic mechanismsAmerican Journal of Physiology-Legacy Content, 1962
- Directed Attack Elicited from HypothalamusArchives of Neurology, 1962