New developments of brain imaging for Parkinson's disease and related disorders
- 27 July 2006
- journal article
- review article
- Published by Wiley in Movement Disorders
- Vol. 21 (12) , 2035-2041
- https://doi.org/10.1002/mds.20845
Abstract
Parkinson's disease (PD) and related disorders are subcortical degenerations targeting the nigrostriatal dopaminergic system and basal ganglia. Traditionally, MRI has been used to detect structural and positron emission tomography and single emission computed tomography functional neurochemical and metabolic changes associated with these disorders. Recently, advances in diffusion‐weighted MRI, ultrasonography, and radiotracer‐based imaging have yielded greater sensitivity for revealing structural change and allowed detection of changes in brain dopamine levels after levodopa and during behavioral tasks. This review focuses on these recent advances in neuroimaging technology and their use for the diagnosis and assessment of PD and other parkinsonian disorders. © 2006 Movement Disorder SocietyKeywords
This publication has 37 references indexed in Scilit:
- Five‐year follow‐up study of hyperechogenicity of the substantia nigra in Parkinson's diseaseMovement Disorders, 2005
- Differentiation of Parkinson's disease and atypical parkinsonian syndromes by transcranial ultrasoundJournal of Neurology, Neurosurgery & Psychiatry, 2005
- Hot spots: Can positron emission tomography offer insights into the pathogenesis of PD?Annals of Neurology, 2005
- Comparison of diffusion‐weighted imaging and [123I]IBZM‐SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's diseaseMovement Disorders, 2004
- Brain parenchyma sonography detects preclinical parkinsonismMovement Disorders, 2004
- Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortexBrain, 2003
- Polymorphism in the P-glycoprotein drug transporter MDR1 genePharmacogenetics, 2003
- Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease: PET evidence of increased dopamine turnoverAnnals of Neurology, 2001
- Quantification of Amphetamine-Induced Changes in [11C]Raclopride Binding with Continuous InfusionJournal of Cerebral Blood Flow & Metabolism, 1997
- Microglia: a sensor for pathological events in the CNSTrends in Neurosciences, 1996