Preparation of 8-Chloropurine Nucleosides Through the Reaction Between their C-8 Lithiated Species andp-Toluenesulfonyl Chloride
- 1 February 1988
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 7 (1) , 121-128
- https://doi.org/10.1080/07328318808068708
Abstract
Chlorination of purine nucleosides protected with tert-butyldimethylsilyl (TBDMS) group was examined by the reaction of the C-8 lithiated species, generated by LDA, with p-toluenesulfonyl chloride as an electrophile. This provides a new method for the preparation of 8-chloropurine nucleosides.This publication has 7 references indexed in Scilit:
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