Effect of Shock on Rat Heart and Brain Mitochondria

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Abstract
Phosphorylation processes were studied in heart and brain mitochondria of rats subjected to severe shock by the Noble-Collip drum, tourniquet and hemorrhage technique. A decreased synthesis of adenosine-triphosphate was found in drum shock. Lowered P/O ratios were obtained with heart mitochondria of all 3 types of shock when compared to normal preparations, and the adenosine-triphosphatase activity was unchanged. After shock, the electrolyte composition of heart mitochondria was altered; the total P and K increased while Na decreased and Mg and Ca showed only slight differences.