Intravenous Self-Administration of Nomifensine in Rats: Implications for Abuse Potential in Humans
- 5 June 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4499) , 1167-1168
- https://doi.org/10.1126/science.7195072
Abstract
Rats acquired and maintained intravenous self-administration of nomifensine, a new antidepressant compound. Additional experiments implicated dopamine-containing neurons in this behavior. These findings, along with the marked pharmacological similarities between nomifensine and such drugs as cocaine and methylphenidate, indicate a potential for nomifensine abuse by humans.Keywords
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