EFFECT OF THYMIC HORMONE ON RESPONSE OF DIFFERENT LYMPHOID-CELL POPULATIONS TO T-MITOGENS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 13  (4) , 363-370
Abstract
The effect of the thymus humoral factor (THF) on the response of different lymphoid cell populations to T [thymus-derived] cell mitogens was studied [in mice]. Lower THF concentrations were required to increase the response to concanavalin A (Con A) than to increase that to phytohemagglutinin (PHA), suggesting that T cell types at various stages of maturation are activated at different THF concentrations. Lower THF concentrations were required to enhance the mitogenic response of thymus cells than to enhance the mitogenic response of spleen cells, possibly because of the higher incidence of target cells for THF activity in the thymus cell population. Spleen cells of adult thymectomized mice exhibited a higher sensitivity for THF than cells of intact control mice. Lymph node cells showed no increase in mitogenic response after THF treatment. Similarly, THF did not affect the mitogenic response of spleen cells from nude mice. Apparently the targets for THF activity are the younger cells within the T cell lineage.

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