B-Cells Promote Intra-Islet CD8+ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes
Open Access
- 1 April 2008
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 57 (4) , 909-917
- https://doi.org/10.2337/db07-1256
Abstract
OBJECTIVE—To determine the role of B-cells in promoting CD8+ T-cell—mediated β cell destruction in chronically inflamed islets.Keywords
This publication has 37 references indexed in Scilit:
- Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in miceJournal of Clinical Investigation, 2007
- Antibody-enhanced cross-presentation of self antigen breaks T cell toleranceJournal of Clinical Investigation, 2007
- Autoantibody markers for the diagnosis and prediction of type 1 diabetesAutoimmunity Reviews, 2006
- B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetesTrends in Endocrinology & Metabolism, 2006
- TACI-BLyS signaling via B-cell–dendritic cell cooperation is required for naive CD8+ T-cell priming in vivoBlood, 2006
- Development of Type 1 Diabetes despite Severe Hereditary B-Cell DeficiencyNew England Journal of Medicine, 2001
- Progression to diabetes in relatives with islet autoantibodies. Is it inevitable?Diabetes Care, 1999
- Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet AntigensImmunity, 1998
- The role of CD4 and CD8 T cells in type I diabetes in the NOD mouseResearch in Immunology, 1997
- CD8 T cell memory in B cell-deficient mice.The Journal of Experimental Medicine, 1996