Effect of Senescence on Macrophage Polarization and Angiogenesis
- 1 February 2008
- journal article
- review article
- Published by Mary Ann Liebert Inc in Rejuvenation Research
- Vol. 11 (1) , 177-185
- https://doi.org/10.1089/rej.2007.0614
Abstract
There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.Keywords
This publication has 70 references indexed in Scilit:
- Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in miceJournal of Clinical Investigation, 2007
- Role of tumor-associated macrophages in tumor progression and invasionCancer and Metastasis Reviews, 2006
- Macrophages Inhibit Neovascularization in a Murine Model of Age-Related Macular DegenerationPLoS Medicine, 2006
- Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapyEuropean Journal Of Cancer, 2006
- Monocyte and macrophage heterogeneityNature Reviews Immunology, 2005
- Collateral Artery Growth (Arteriogenesis) After Experimental Arterial Occlusion Is Impaired in Mice Lacking CC-Chemokine Receptor-2Circulation Research, 2004
- An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient miceNature Medicine, 2003
- Alternative activation of macrophagesNature Reviews Immunology, 2003
- The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapiesThe Journal of Pathology, 2002
- Phenotypic and functional characteristics of circulating monocytes of elderly persons☆Experimental Gerontology, 1999