Upper Gastrointestinal Bleeding in Patients with Chronic Renal Failure

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Abstract
Endoscopy to evaluate upper gastrointestinal bleeding was done for 482 patients over a 42 mo. period. Fifty-nine patients (12%) had chronic renal failture and upper gastrointestinal bleeding; the remaining 423 did not have renal failture. Angiodysplasia of the stomach or duodenum was the most frequent source of bleeding in patients with renal failure. Angiodysplasia (P < 0.001) and erosive esophagitis (P < 0.01) were significantly commoner causes of bleeding in the renal failure population than in the group without renal failure. Recurrent bleeding was also more frequent in patients with renal failure (25%) than in the other patients (11%). Angiodysplasia was the most frequent source of recurrent bleeding in patients with renal failure (53%) whereas peptic lesions were the most likely sources in those without renal failure (51%). The differential diagnoses of 1st and subsequent upper gastrointestinal bleeding sites differ for patients with and without chronic renal failure.