Induction of Malignant Bone Tumors in Rats by 1- (2-Hydroxyethyl) -1 -nitrosourea2
- 1 February 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (2) , 445-446
- https://doi.org/10.1093/jnci/56.2.445
Abstract
Forty male MRC-W rats were treated chronically with 1-(2-hydroxyethyl)-1-nitrosourea in drinking water (total dose, 330 mg/rat). Fifteen rats (38%) developed osteogenic osteosarcomas or chondrosarcomas of the lower vertebrae. This was the first time that an orally administered organic compound induced a high incidence of these tumors.Keywords
This publication has 0 references indexed in Scilit: