De novo Development of Hypercholesterolemia and Elevated High-Density Lipoprotein Cholesterol: Apoprotein A-I Ratio in Patients with Chronic Renal Failure following Kidney Transplantation

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Abstract
Serum lipids, apoprotein and lecithin-cholesterol acyltransferase activities were studied in 27 renal transplant recipients with stable and normal renal function (serum creatinine 0.16 mM/l or less) sustained for > 1 yr following grafting. Hypertriglyceridemia, which was characteristic of hyperlipidemia in 18 hemodialyzed patients with chronic renal failure, was no longer manifest in transplant recipients. De novo hypercholesterolemia was observed posttransplant with mean serum levels of 5.82 .+-. 1.34 vs. 5.01 .+-. 0.88 mM/l in 575 normal controls. Cholesterol content (1.72 .+-. 0.56 mM/l) was significantly higher in transplant patients than in hemodialyzed patients (0.82 .+-. 0.31 mM/l). No variation in apoprotein A-I levels was found between both groups of patients, producing an elevated high-density lipoprotein cholesterol:apoprotein A-I ratio. Derangement in the serum lipid profile, although qualitatively different, continued to be present following transplantation; its relevance to cardiovascular morbidity in these patients remains to be evaluated.