A High-Affinity Arg-X-X-Lys SH3 Binding Motif Confers Specificity for the Interaction between Gads and SLP-76 in T Cell Signaling
Open Access
- 1 August 2002
- journal article
- research article
- Published by Elsevier in Current Biology
- Vol. 12 (15) , 1336-1341
- https://doi.org/10.1016/s0960-9822(02)01038-2
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replicationNature, 2001
- Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFATMolecular and Cellular Biology, 2001
- Requirement for the SLP-76 Adaptor GADS in T Cell DevelopmentScience, 2001
- The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifOncogene, 2001
- A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKPJournal of Biological Chemistry, 2000
- Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine KinasesJournal of Biological Chemistry, 2000
- Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological ResponsesThe Journal of cell biology, 2000
- Molecular Cloning and Expression of HumanGrap-2, a Novel Leukocyte-Specific SH2- and SH3-Containing Adaptor-like Protein That Binds toGab-1Biochemical and Biophysical Research Communications, 1998
- The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein–protein interactionsCurrent Biology, 1996
- Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.The Journal of Experimental Medicine, 1996