Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members
- 3 December 1993
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 262 (5139) , 1557-1560
- https://doi.org/10.1126/science.8248803
Abstract
The E2F family of transcription factors functions in the control of the mammalian cell cycle. Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.Keywords
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