Spikes-Wave From Stimulation of Reticular Core

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Abstract
Lesions in the rostral midbrain have been found in various species to produce a syndrome characterized by depressed consciousness varying in degree from coma to drowsiness. Related symptoms include hypokinesia, slowed movements, mask-like facies, and mutism (Magoun, 1954, Rossi and Zanchetti, 1957, Crosby et al, 1962). Hubel and Nauta, 1960, produced lesions at the mesodiencephalic junction in cats. In the first postoperative week the cats were awake but catatonic. Following this, they began having attacks of 3-5/sec spikes-wave accompanied by facial twitching which were triggered by photic stimulation and abolished by arousal stimulation. Batsel, 1960, also observed spontaneous bursts of 3-4/sec spikes-wave occurring in dogs following brain stem section. Implantation of alumina into the mesencephalic reticular formation in kittens led to the development of spikes-wave EEG patterns accentuated by photic stimulation and hyperventilation. Similar discharges appeared, after a longer interval, following intralaminar thalamic injections but not after placements in other

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