Crystal structure of RVV‐X: An example of evolutionary gain of specificity by ADAM proteinases
- 3 December 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (30) , 5859-5864
- https://doi.org/10.1016/j.febslet.2007.11.062
Abstract
Russell's viper venom factor X activator (RVV-X) is a heterotrimeric metalloproteinase with a mammalian ADAM-like heavy chain and two lectin-like light chains. The crystal structure of RVV-X has been determined at 2.9 A resolution and shows a hook-spanner-wrench-like architecture, in which the metalloproteinase/disintegrin region constitutes a hook, and the lectin-like domains constitute a handle. A 6.5nm separation between the catalytic site and a putative exosite suggests a docking model for factor X. The structure provides a typical example of the molecular evolution of multi-subunit proteins and insights into the molecular basis of target recognition and proteolysis by ADAM/adamalysin/reprolysin proteinases.Keywords
This publication has 20 references indexed in Scilit:
- Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteinsFEBS Letters, 2007
- Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffoldThe EMBO Journal, 2006
- ADAMs: modulators of cell–cell and cell–matrix interactionsCurrent Opinion in Cell Biology, 2003
- The ADAMs family of metalloproteases: multidomain proteins with multiple functionsGenes & Development, 2003
- Crystal Structure of Flavocetin-A, a Platelet Glycoprotein Ib-Binding Protein, Reveals a Novel Cyclic Tetramer of C-Type Lectin-like Heterodimers,Biochemistry, 2000
- Coagulation Factor X-Binding Protein from Deinagkistrodon acutus Venom Is a Gla Domain-Binding ProteinBiochemistry, 1998
- Structure of the Calcium-Dependent Lectin Domain from a Rat Mannose-Binding Protein Determined by MAD PhasingScience, 1991
- The role of the Gla domain in the activation of bovine coagulation factor X by the snake venom protein XCPBiochemical and Biophysical Research Communications, 1983
- Factor X activating enzyme from Russell's viper venom: isolation and characterizationBiochemistry, 1976
- Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activationBiochemistry, 1970