Studies of the LSA Ascites Lymphoma of C57BL Mice. I. Transplantation Characteristics and Radiosensitivity of Cells During Serial Passages2

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Abstract
A new transplantable tumor, the LSA ascites lymphoma of the C57BL/Ka mouse, was used in radiobiological experiments. A progressive increase in the transplantability of the tumor was observed with serial passage. The sensitivity of the cells to X rays was studied in early and late passage. The increased radioresistance of late passage cells can be accounted for on the basis of hypoxia after an increase in ascites volume.

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