Enantioselective Synthesis of (R)- and (S)-Cizolirtine; Application of Oxazaborolidine-Catalyzed Asymmetric Borane Reduction to Azolyl Phenyl Ketones
- 1 June 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (6) , 765-767
- https://doi.org/10.1055/s-1999-2712
Abstract
An efficient enantioselective synthesis of (R)- and (S)-cizolirtine 1 is described. The key step of the procedure is the CBS-oxazaborolidine asymmetric reduction of phenyl pyrazolyl ketone 2. Related enantioselective reductions of several azolyl phenyl ketones are also reported.Keywords
This publication has 0 references indexed in Scilit: