Impaired Vision after Prolonged Chloroquine Therapy

Publisher Website
Google Scholar
Abstract
SINCE the introduction of chloroquine (7-chlor-4–4-diethylamino-1-methylaminoquinidine) as an antimalarial drug its use has been recommended in the treatment of such diverse illnesses as lupus erythematosus, rheumatoid arthritis, parasitic infestation, cutaneous sarcoid and certain cardiac arrhythmias. It had been considered a relatively safe drug, and prolonged therapy was reported to be only occasionally associated with such minor side effects as dermatitis, diplopia, blurred vision and bleaching of the hair. These quickly disappeared upon withdrawal of the drug.1 More recently, reports of corneal infiltrates occurring with prolonged chloroquine therapy have appeared in the literature.2 , 3 The symptoms associated with these lesions were blurred . . .