Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity
- 1 February 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 111 (2) , 151-153
- https://doi.org/10.1530/acta.0.1110151
Abstract
The response of plasma hGH to an iv bolus injection of GRH1-44 (1 .mu.g/kg) was studied in 14 obese juveniles with a mean overweight of 4.7 .+-. 0.05 standard deviation score (SDS). Two patterns of response were observed: in all 7 adolescents with ''simple'' obesity not related to any particular disorder (group A) the response was good (a mean of 11.8 .+-. 2.4 ng/ml) whereas in 6 of the 7 juveniles suffering from syndromes associated with obesity (group B) the response was poor (a mean of 3.2 .+-. 1.4 ng/ml). This divergence in response could not be related to a difference in the degree of overweight. These results indicate that in group B with syndromes associated with obesity there may also be a pituitary impairment in addition to the hypothalamic defect.This publication has 5 references indexed in Scilit:
- Plasma Growth Hormone Response to Synthetic GH-RH1-44 in 52 Children and Adults with Growth Hormone Deficiency of Various EtiologiesHormone Research, 1985
- Impaired Growth Hormone Responses to Growth Hormone–Releasing Factor in ObesityNew England Journal of Medicine, 1984
- DIFFERENTIAL DIAGNOSIS BETWEEN HYPOTHALAMIC AND PITUITARY hGH DEFICIENCY WITH THE AID OF SYNTHETIC GH‐RH 1–44Clinical Endocrinology, 1984
- Abnormalities of growth hormone release in response to human pancreatic growth hormone releasing factor (GRF (1-44) ) in acromegaly and hypopituitarism.BMJ, 1983
- Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesityMetabolism, 1982