MAP kinases and cell migration
Top Cited Papers
- 15 September 2004
- journal article
- review article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 117 (20) , 4619-4628
- https://doi.org/10.1242/jcs.01481
Abstract
Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs), including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK, for example, regulates cell migration by phosphorylating paxillin, DCX, Jun and microtubule-associated proteins. Studies of p38 show that this MAPK modulates migration by phosphorylating MAPK-activated protein kinase 2/3 (MAPKAP 2/3), which appears to be important for directionality of migration. Erk governs cell movement by phosphorylating myosin light chain kinase (MLCK), calpain or FAK. Thus, the different kinases in the MAPK family all seem able to regulate cell migration but by distinct mechanisms.Keywords
This publication has 128 references indexed in Scilit:
- FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassemblyNature Cell Biology, 2004
- A role for MEK kinase 1 in TGF- /activin-induced epithelium movement and embryonic eyelid closureThe EMBO Journal, 2003
- JNK phosphorylates paxillin and regulates cell migrationNature, 2003
- Disruption of Basal JNK Activity Differentially Affects Key Fibroblast Functions Important for Wound HealingJournal of Biological Chemistry, 2003
- Cooperativity between the Ras-ERK and Rho-Rho Kinase Pathways in Urokinase-type Plasminogen Activator-stimulated Cell MigrationJournal of Biological Chemistry, 2002
- c-Jun N-terminal kinase is involved in motility of endothelial cellExperimental & Molecular Medicine, 2001
- Tensin Can Induce JNK and p38 ActivationBiochemical and Biophysical Research Communications, 2000
- Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during AngiogenesisThe Journal of cell biology, 1998
- Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessNature, 1997
- The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.Genes & Development, 1996