Regulation of cell size in the yeast Saccharomyces cerevisiae

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Abstract
For cells of the yeast S. cerevisiae, the size at initiation of budding is proportional to growth rate for rates from 0.33 to 0.23 h-1. At growth rates lower than 0.23 h-1, cells displayed a minimum cell size at bud initiation independent of growth rate. Regardless of growth rate, cells displayed an increase in volume each time budding was initiated. When abnormally small cells, produced by starvation for N, were placed in fresh medium containing N, but with different C sources, they did not initiate budding until they had grown to the critical size characteristic of that medium. When cells were shifted from a medium supporting a low growth rate and small size at bud initiation to a medium supporting a higher growth rate and larger size at bud initiation, there was a transient accumulation of cells within G1. Yeast cells are apparently able to initiate cell division at different cell sizes and that regulation of cell size occurs within G1.