Evidence for the Association of Human Papillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Immunocompetent Individuals

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Abstract
HUMAN PAPILLOMAVIRUSES (HPVs) are small DNA viruses that infect epithelial cells and induce a variety of proliferative lesions, such as warts, laryngeal papillomas, and cervical carcinoma.1,2 In addition to their role in anogenital cancer3,4 and probably in squamous cell carcinoma (SCC) of the head and neck,5,6 they are also associated with the development of skin cancer in individuals with epidermodysplasia verruciformis (EV), a rare inherited condition characterized by widespread HPV infection and eventual development of multiple SCCs, predominantly on sun-exposed sites.2