A Cyclic AMP Analogue Induces Synthesis of a Myelin‐Specific Glycoprotein by Cultured Schwann Cells
- 1 January 1988
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 50 (1) , 190-194
- https://doi.org/10.1111/j.1471-4159.1988.tb13248.x
Abstract
Neontal rat Schwann cells, cultured with agents which increase intracellular cyclic AMP, were prompted to resume synthesis of a 170,000 Mr glycoprotein which is specific to peripheral nervous system myelin and is herein referred to as P170K. We have shown previously that similar treatment indices the synthesis by Schwann cells of the myelin lipid, galactocerebroside. In contrast to P170K and galactocerebroside, syntheses of P0 and myelin basis protein were not induced. Intracellular cyclic AMP is thus likely to be a participant in the complex system regulating myelination.Keywords
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