[1,2-Benzenediolato(2−)-O-O′]oxotitanium. A Chemoselective and Efficient Catalyst for Aldol-type Reaction of Ketene Silyl Acetals with Aldehydes
- 1 November 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 18 (11) , 1909-1912
- https://doi.org/10.1246/cl.1989.1909
Abstract
In the presence of a catalytic amount of [1,2-benzenediolato(2−)-O,O′]oxotitanium, ketene silyl acetals smoothly react with aldehydes to afford the corresponding β-hydroxy carboxylic esters in good yields under mild conditions. According to this procedure, an aldehyde group is selectively activated, while an acid labile acetal group remains intact.Keywords
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