Relative Effects of α- and γ-Tocopherol on Low-Density Lipoprotein Oxidation and Superoxide Dismutase and Nitric Oxide Synthase Activity and Protein Expression in Rats
- 1 December 1999
- journal article
- Published by SAGE Publications in Journal of Cardiovascular Pharmacology and Therapeutics
- Vol. 4 (4) , 219-226
- https://doi.org/10.1177/107424849900400403
Abstract
Background: Increasing evidence suggests that vitamin E prevents the progression of ath erosclerosis by inhibiting platelet aggregation, monocyte adhesion. and improving plaque stability and vasomotor function. Recently, controversy has arisen as to the relative effects of α- and γ-tocopherol in modulating some mediators of atherosclerosis.Keywords
This publication has 39 references indexed in Scilit:
- Antioxidants and Atherosclerotic Heart DiseaseNew England Journal of Medicine, 1997
- Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation.Journal of Clinical Investigation, 1996
- Dietary Antioxidant Vitamins and Death from Coronary Heart Disease in Postmenopausal WomenNew England Journal of Medicine, 1996
- Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)The Lancet, 1996
- Experimental thrombosis model induced by free radicals. Application to aspirin and other different substancesThrombosis Research, 1995
- Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.Journal of Clinical Investigation, 1995
- Free oxygen radicals contribute to platelet aggregation and cyclic flow variations in stenosed and endothelium-injured canine coronary arteriesJournal of the American College of Cardiology, 1994
- Vitamin E Consumption and the Risk of Coronary Heart Disease in MenNew England Journal of Medicine, 1993
- Vitamin E Consumption and the Risk of Coronary Disease in WomenNew England Journal of Medicine, 1993
- The Pathogenesis of Coronary Artery Disease and the Acute Coronary SyndromesNew England Journal of Medicine, 1992