DECIDUOMA FORMATION IN RATS DURING TESTOSTERONE TREATMENT11

Publisher Website
Google Scholar
Abstract
It has been possible to produce deciduomata by traumatization of the uteri of both adult and immature rats during the course of daily subcut. injs. of testosterone propionate. This effect, however, was only obtained when the ovaries contained hypertrophied corpora lutea similar to those seen during pregnancy, so that it is attributed not to a direct action of testosterone on the uterus but to the presence of progestin. In order to induce the forma tion of such large corpora the initial inj. of testosterone must be given during the early stage of their development. Deciduomata were produced in only a small proportion of the immature animals employed, possible because of a prepubertal insensitivity of this type of treatment.