Extrinsic and intrinsic determinants of the host response in environmental lung disease

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Abstract
The development of lung disorders of environmental origin depends on a host response and the circumstances of exposure to noxious inhalable material. Climate, geography, culture, level of physical activity and the quality of indoor and outdoor air are important extrinsic variables. Host susceptibility is influenced by variable mechanisms which comprise plumonary defence. Few of these mechanisms are fully understood and most require more precise definition.