Aromatic Compound-Dependent Brucella suis Is Attenuated in Both Cultured Cells and Mouse Models
Open Access
- 1 January 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (1) , 547-550
- https://doi.org/10.1128/iai.69.1.547-550.2001
Abstract
The aroC gene of the facultative intracellular pathogenBrucella suis was cloned and sequenced. The clonedaroC gene complements Escherichia coli andSalmonella enterica serovar Typhimurium aroCmutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in tissue culture (THP1 macrophages and HeLa cells) and murine virulence models.Keywords
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