Glucose tolerance in the elderly: the role of insulin and its receptor

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Abstract
Oral glucose tolerance tests were performed in young and elderly subjects with minimal risk factors for diabetes mellitus. Compared to the normal glucose tolerance in the young there was a 45% rate of impaired tolerance in the elderly. Fasting insulin levels were significantly lower in the elderly but post-glucose insulin responses in the 1st hour were similar in young and elderly subjects. Peripheral insulin action was assessed in terms of the 125monoiodoinsulin binding to specific insulin receptor sites on circulating lymphocytes in the young, the elderly and a group of age and sex matched obese maturity-onset diabetics. Specific insulin binding was not significantly different in the elderly than in the young but was significantly lower in the diabetics than the young and the elderly. The results suggest that neither defective insulin secretion nor reduced peripheral insulin binding are major causative factors in the reduced glucose tolerance of the elderly.