Cellular and metabolic tolerance to an opioid narcotic in mouse brain
Open Access
- 1 January 1973
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 47 (1) , 138-140
- https://doi.org/10.1111/j.1476-5381.1973.tb08167.x
Abstract
1 Running activity and brain levorphanol concentration were measured in nontolerant and tolerant mice given various doses of 3H-levorphanol. 2 The principal factor responsible for tolerance in the mouse is a loss of sensitivity to the narcotic drug at the cellular level in brain; despite adequate brain concentrations, the pharmacological effects are diminished or absent. 3 There is also metabolic tolerance; a given dose establishes a lower brain concentration in tolerant than in non-tolerant animals. 4 The two kinds of tolerance are distinguished here and the contribution of each is assessed.Keywords
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