Toxic effects of isoniazid in tuberculosis chemoprophylaxis. Role of biochemical monitoring in 1,000 patients
- 23 March 1979
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 241 (12) , 1239-1241
- https://doi.org/10.1001/jama.241.12.1239
Abstract
Patients [1000] receiving isoniazid chemoprophylaxis were prospectively followed up to assess the value of liver function monitoring plus monthly clinical evaluation. Two hundred twenty-two (22.2%) of the patients had at least 1 elevated SGOT [serum glutamine oxaloacetate transaminase] level during the course of treatment, and 47 asymptomatic persons had isoniazid therapy discontinued because of consistent elevations greater than 5 .times. normal. Another 17 had symptoms in association with elevated SGOT levels, and therapy was stopped in these patients as well. No patient became seriously ill, and there were no deaths. Biochemical monitoring should be done routinely in patients receiving isoniazid chemoprophylaxis to avoid the development of irreversible hepatic reactions.This publication has 6 references indexed in Scilit:
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