Lupulon--An Antibiotic Extracted from the Strobiles of Humulus lupulus.

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Abstract
Lupulon, an antibiotic ex-tracted from hop resins, was found to be effective against Gram-positive bacteria in vitro but inactive against Gram-negative organisms. The antibiotic had no demonstrable effect on a no. of pathogenic and nonpathogenic molds and actinomycetes. Lupulon displayed no activity in the presence of horse serum. In the absence of serum the antibiotic exhibited its greatest activity against Mycobacterium tuberculosis H37Rv. This may have been due to the fact that the tubercle bacillus was cultivated in a mineral medium with only an appreciable amt. of interfering organic matter whereas the other organisms were grown in a medium containing peptone. Addition of serum to both media completely inactivated the antibiotic. Lupulon is slowly inactivated in the presence of air and more rapidly in the presence of serum. Because of its in-activation by serum, the antibiotic is not suitable for clinical admn.

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