Macromolecular Binding of Estradiol in the Rabbit Oviduct and Uterus

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Abstract
Macromolecular binding of estradiol in the ampullary and isthmic portions of the rabbit oviduct and the rabbit uterus was examined by in vivo uptake studies, sucrose gradient centrifugation, and binding assays. The studies revealed that the in vivo uptake was similar in the 3 mullerian areas examined. In addition, the estrogen receptor complex from all 3 areas had almost identical sedimentation characteristics in sucrose gradient centrifugation. Finally, the binding assays revealed that the number of estrogen-binding sites and the dissociation constants were similar in the 3 areas studied. These results indicate that the initial interaction of estrogen with the uterus and both portions of the oviduct is identical.

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