In vivo31P NMR spectroscopy of agonist‐stimulated phosphatidylinositol metabolism in cat brain

Abstract
As a result of the agonist stimulation of muscarinic receptors, myc-inositol-1 -phosphate accumulates in the presence of millimolar lithium concentrations. This accumulation of myo-inositol-1 -phosphate can be detected by in vivo 31P NMR spectroscopy. Since myo-inositol-1-phosphate is a breakdown product of phosphatidylinositol, this may provide a means of noninvasively monitoring phosphatidylinositol metabolism in vivo. © 1987 Academic Press, Inc.