The Radiation Sensitivity of a Transplanted Murine Lymphoma as Determined by Two Different Assay Methods

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Abstract
The radiation sensitivity of a line of transplanted murine lymphoma cells was found to be characterized by a Do of 114 + 4 rads when the spleen-colony method was used to assay viability, but was 133 + 8 rads when a serial dilution assay was used. The difference could not be attributed to a change in the fraction of colony-forming cells that reached the spleen post irradiation, to a homograft reaction to the cells, or to a separate identity of "colony-forming" and "malignant" cells. The difference may be due either to a post-irradiation heterogeneity in the growth properties of the irradiated cells or to a difference in the survival of lymphoma cells depending on their postirradiation environment.

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