In vitro activity of HR 810, a new broad-spectrum cephalosporin

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Abstract
HR 810, 3-〈(2,3-cyclopenteno-l -pyridinium)methyl〉-7-〈2-syn-methoximino-2-(2-aminothiazole-4-yl)-acetamido〉 ceph-3-em-4-carboxylate, is a new semisynthetic cephalosporin derivative. The in vitro activity of HR810 was compared with that of cefotaxime, ceftazidime, piperacillin and gentamicin using 368 strains of gram-negative and gram-positive bacteria. HR 810 was highly active againstEnterobacteriaceae, being the most active of the cephalosporins againstEnterobacter, Serratia andCitrobacter spp.; the MICs ranged from ≤0.06 to 8mg/l. The activity of HR 810 againstPseudomonas aeruginosa andAcinetobacter spp. was almost as good as that of ceftazidime. The new compound was superior to the other cephalosporins againstStaphylococcus aureus and inhibited allStreptococcus faecalis strains at a concentration of 16 mg/l.