Delayed Hypersensitivity to Hepatitis-associated Antigen in Guinea Pigs

1 January 1972

journal article
research article
Published by Oxford University Press (OUP) in The Journal of Infectious Diseases

Vol. 125 (1) , 73-76
https://doi.org/10.1093/infdis/125.1.73

Abstract

A model for the study of delayed hypersensitivity to hepatitis-associated antigen (HAA) in guinea pigs was designed. Guinea pigs immunized with purified HAA plus Freund's complete adjuvant developed a positive skin reaction when they were inoculated intradermally with HAA 17 to 35 days later. This reaction is characterized by erythema and induration that reaches a maximum at 24 to 36 hr and then subsides over the next 48 hr. Histologic examination of the skin lesions shows an infiltrate of predominantly mononuclear cells. Heating HAA for 1 min at 37 C, 57 C, 75 C, or 98 C does not modify its activity as an immunizing or skin-reactive agent.

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