Nectadrin, the heat-stable antigen, is a cell adhesion molecule.
Open Access
- 1 September 1992
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 118 (5) , 1245-1258
- https://doi.org/10.1083/jcb.118.5.1245
Abstract
Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoproteins, and in many cases appear to have more than one subunit capable of binding the hormone. The interaction of the hormone or neurotransmitter with its receptor is rapid, reversible, and of high affinity and specificity. Many receptors exhibit cooperative properties in hormone binding or biological function. The concentration of receptors on the membrane is a function of continued synthesis and degradation, and may be altered by a variety of factors including the hormone itself. The fluid mosaic nature of the membrane may allow hormone receptors and effectors to exist in free floating states. Further investigations of the hormone-receptor interaction will no doubt yield new insights into both the mechanism of hormone action and membrane structure and function.Keywords
This publication has 55 references indexed in Scilit:
- The murine heat‐stable antigen: a differentiation antigen expressed in both the hematolymplioid and neural cell lineagesEuropean Journal of Immunology, 1991
- Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell LocomotionAnnual Review of Immunology, 1991
- Carbohydrate ligands of the LEC cell adhesion moleculesCell, 1990
- The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.The Journal of cell biology, 1990
- Structural basis for altered soybean agglutinin lectin binding between a murine metastatic lymphoma and an adhesive low malignant variantExperimental Cell Research, 1987
- The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune SystemAnnual Review of Immunology, 1987
- Selective expression of the 180-kD component of the neural cell adhesion molecule N-CAM during development.The Journal of cell biology, 1985
- Carbohydrate moieties of glycoproteins a re-evaluation of their functionBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1982
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970