A suppressor T cell in the human mixed lymphocyte reaction.
Open Access
- 1 August 1977
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 146 (2) , 368-380
- https://doi.org/10.1084/jem.146.2.368
Abstract
Lymphocytes from an HL-A-B7 DW2 homozygous multiparous woman failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband and certain other homozygous typing cells. Her lymphocytes could suppress the response of HL-A matched responders to his. This effect was radiosensitive and due to a T [thymus-derived] cell. The suppressor cell showed antigen specificity.Keywords
This publication has 16 references indexed in Scilit:
- Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.The Journal of Experimental Medicine, 1976
- A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.The Journal of Experimental Medicine, 1976
- Use of High Dose X‐Irradiation to Block Back Stimulation in the MLC ReactionTissue Antigens, 1976
- Regulation of Immunoglobulin and Antibody Production Allotype Suppressor T Cells in MiceImmunological Reviews, 1975
- Properties of Primed Suppressor T Cells and their ProductsImmunological Reviews, 1975
- Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.The Journal of Experimental Medicine, 1975
- ROLE OF SUPPRESSOR T CELLS IN PATHOGENESIS OF COMMON VARIABLE HYPOGAMMAGLOBULINÆMIAThe Lancet, 1974
- GENETIC CONTROL OF IMMUNE RESPONSES IN VITROThe Journal of Experimental Medicine, 1974
- Regulation of the antibody response to type 3 pneumococcal polysaccharide. IV. Role of suppressor T cells in the development of low-dose paralysis.1974
- COOPERATING AND CONTROLLING FUNCTIONS OF THYMUS-DERIVED LYMPHOCYTES IN RELATION TO AUTOIMMUNITYThe Lancet, 1971