Assignment of the human PAX4 gene to chromosome band 7q32 by fluorescence in situ hybridization
- 1 January 1994
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 66 (2) , 132-134
- https://doi.org/10.1159/000133684
Abstract
Of the nine known members of a human paired box-containing gene family (Pax), only PAX4 has not been precisely localized. We screened a cosmid library of human genomic DNA using polymerase chain reaction products for PAX4 as a probe and isolated three positive cosmid clones. Sequence analysis revealed that at least two of them had exon-like sequences and showed extensive homology to Pax-4 in the mouse. These two cosmid clones were mapped to human chromosome band 7q32 by fluorescence in situ hybridization.Keywords
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