TREATMENT OF MIGRAINE WITH PEPTONE

30 June 1923

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 80 (26) , 1894-1896
https://doi.org/10.1001/jama.1923.02640530006002

Abstract

Three years ago, Pagniez, Vallery-Radot and Nast¹published a report on the treatment of migraine by the intravenous injection of horse serum, later substituting peptone for the serum. At this time they advanced the view that the migraine seizure was an anaphylactic manifestation. Independently, Abel²during the same year, reported the results of treating 100 cases of migraine by intramuscular injection of a placental extract. He was led to select the placenta for making an extract on account of the frequent disappearance of the disease during pregnancy. His theory of the method of action was not one of desensitization, but rather of some obscure endocrine effect. Becoming interested in this subject from reading these reports, we have treated during the last two years twenty-five migrainous patients. The results have been sufficiently striking to lead us to conclude that migraine is definitely benefited by this procedure, and we have

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